Evaluating the hematological & clinical-chemistry of kratom

Evaluating the hematological and clinical-chemistry parameters of kratom (Mitragyna speciosa) users in Malaysia

Abstract
Ethnopharmacological relevance
Kratom (Mitragyna speciosa Korth.) from the Rubiaceae family is an indigenous tropical medicinal tree of Southeast Asia. Kratom leaves have been used for decades in Malaysia and Thailand in traditional context for its perceived vast medicinal value, and as a mild stimulant among manual laborers. Kratom consumption has been reported to cause side-effects in kratom users.

Aim of the study
To evaluate kratom's effects towards hematological and clinical-chemistry parameters among regular kratom users in Malaysia.

Methods
A total of 77 subjects (n=58 regular kratom users, and n=19 healthy controls) participated in this cross-sectional study. All the surveys were conducted through a face-to-face interview to elicit subject's socio-demographic characteristics and kratom use history. A full-blood test was also administered. Laboratory analysis was conducted using GC-MS to determine mitragynine content in the acquired kratom samples in order to relate mitragynine consumption with possible alterations in the blood parameters of kratom users.

Results
Findings showed that there were no significant differences in the hematological and clinical-chemistry parameters of traditional kratom users and healthy controls, except for HDL and LDL cholesterol values; these were found to be above the normal reference range for the former. Similarly, long-term kratom consumption (>5 years), and quantity of daily kratom use (≥3 ½ glasses; mitragynine content 76.3–114.8 mg) did not appear to alter the hematological and biochemical parameters of kratom users.

Conclusion
These data suggest that even long-term and heavy kratom consumption did not significantly alter the hematological and clinical-chemistry parameters of kratom users in a traditional setting.
Graphical abstract

Received 22 August 2017
Revised 11 December 2017
Accepted 13 December 2017
Available online 15 December 2017.

Great! That's all I need is more Cholesteral.  :dodgy:

@'Bizaro22':

Great! That's all I need is more Cholesteral.  :dodgy:

No more chicken fried Kratom for Biz :@
But on the plus side you can have a cognac or scotch.

Grower staff Flowers

Sounds like a good dinner to me ^

It's refreshing to see the data resolve what we have all felt for a long while.

@'Bizaro22':

Great! That's all I need is more Cholesteral.  :dodgy:

But it raises the HDL, that’s the good one.

@'Monica Jones':

But it raises the HDL, that’s the good one.

Yes, it does!!!
It lowers LDL (bad) & raises HDL (good).

Liking you more & more, Monica  :shy:

I was wondering if that was the good cholesterol or not. Thank you! Back to my chicken fried Kratom.